Review



shp2 gene  (Addgene inc)


Bioz Verified Symbol Addgene inc is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 93
      Buy from Supplier

    Structured Review

    Addgene inc shp2 gene
    Shp2 Gene, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shp2 gene/product/Addgene inc
    Average 93 stars, based on 2 article reviews
    shp2 gene - by Bioz Stars, 2026-02
    93/100 stars

    Images



    Similar Products

    shp2 inhibitors  (Sino Biological)
    93
    Sino Biological shp2 inhibitors
    Shp2 Inhibitors, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shp2 inhibitors/product/Sino Biological
    Average 93 stars, based on 1 article reviews
    shp2 inhibitors - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier
    gene exp ptpn11 mm00448434 m1  (Thermo Fisher)
    94
    Thermo Fisher gene exp ptpn11 mm00448434 m1
    Gene Exp Ptpn11 Mm00448434 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gene exp ptpn11 mm00448434 m1/product/Thermo Fisher
    Average 94 stars, based on 1 article reviews
    gene exp ptpn11 mm00448434 m1 - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    shp2 gene  (Addgene inc)
    93
    Addgene inc shp2 gene
    Shp2 Gene, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/shp2 gene/product/Addgene inc
    Average 93 stars, based on 1 article reviews
    shp2 gene - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier
    gene sequence encoding shp2 residues met1-leu525  (GenScript corporation)
    90
    GenScript corporation gene sequence encoding shp2 residues met1-leu525
    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for <t>SHP2.</t> (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Gene Sequence Encoding Shp2 Residues Met1 Leu525, supplied by GenScript corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gene sequence encoding shp2 residues met1-leu525/product/GenScript corporation
    Average 90 stars, based on 1 article reviews
    gene sequence encoding shp2 residues met1-leu525 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    primers of genes including bax, bcl-2, caspase3, igf-1, shp2, erk and runx2  (Sangon Biotech)
    90
    Sangon Biotech primers of genes including bax, bcl-2, caspase3, igf-1, shp2, erk and runx2
    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for <t>SHP2.</t> (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Primers Of Genes Including Bax, Bcl 2, Caspase3, Igf 1, Shp2, Erk And Runx2, supplied by Sangon Biotech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primers of genes including bax, bcl-2, caspase3, igf-1, shp2, erk and runx2/product/Sangon Biotech
    Average 90 stars, based on 1 article reviews
    primers of genes including bax, bcl-2, caspase3, igf-1, shp2, erk and runx2 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    sh2  (Sino Biological)
    93
    Sino Biological sh2
    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for <t>SHP2.</t> (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.
    Sh2, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sh2/product/Sino Biological
    Average 93 stars, based on 1 article reviews
    sh2 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: IC 50 (half maximal inhibitory concentration) of inhibitors determined by dose–response assay for SHP2. (A) Dose–inhibition curve of SHP099. (B) Dose–inhibition curve of PB17-026-01.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques: Concentration Assay, Inhibition

    Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: Data collection statistics for crystals of PB17-026-01 and SHP2 complexes, PB17-036-01 and SHP2 complexes.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques:

    (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: (A) Interactions between PB17-026-01 and SHP2. (B) Interactions between PB17-036-01 and SHP2. (C) Superposition of the co-crystal structures of SHP2 in complex of SHP099 (salmon) and PB17-026-01 (yellow). Compared with SHP099, PB17-026-01 lacks the hydrogen bond with E250 but forms hydrogen bond with T253, meanwhile it is hydrogen-bonded with N ε instead of N η of R111. (D) Superposition of the co-crystal structures of SHP2 in the complex of PB17-036-01 (pink) and PB17-026-01 (yellow). The terminal group of PB17-026-01 is hydrogen-bonded with four residues T108, E110, F113, and T253, whereas the terminal group of PB17-036-01 is only hydrogen-bonded with F113 and E249.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques:

    Structure solution and refinement. Values for the outer shell are given in parentheses.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one

    doi: 10.1080/14756366.2022.2151594

    Figure Lengend Snippet: Structure solution and refinement. Values for the outer shell are given in parentheses.

    Article Snippet: The gene sequence encoding SHP2 residues Met1-Leu525 (UniProt accession code Q06124) was synthesised by GenScript (GenScript.com) with codon optimisation for E. coli expression and inserted into pET-15b containing an N-Terminal 6 × His-tag and a tobacco etch virus (TEV) cleavage site.

    Techniques: